Absolutely. I'm no scholar but I can't help but think that John had read about those 666 talents of gold that King Solomon obtained. Maybe it doesn't mean a thing or maybe it meant "something" for the Jews in regard to Solomon.
I think the parallel to Israel descending into "idolatry and bureaucratic controls" is interesting, and then of course subsequent judgment via Assyria and Babylon as was predicted in advance by Jewish prophets. The thing is, there is no greater parallel for that than what happened at the time of Christ, i.e. the 1st century culminating with Jerusalem's (and the Temple's) physical destruction by Rome in AD70. After all, the Pharisaical Jewish element condemned Israel's true Messiah to death and were judged for it just as predicted in advance by that same Messiah, the Prophet Jesus.
Nowadays we like to assume that our time is a better parallel to those things, but the 1st century was truly a time of revolutionary cultural, political, spiritual changes as well as judgment and persecution. Of course, the cultural, political, spiritual, etc. messages of the Bible are always relevant, but I doubt John was specifically referring to 20th and 21st century events.
This letters for numbers and vice versa is confusing. I try to keep the proper perspective of a couple thousand years or so since all these events in the New Testament took place. There is ample talk of the spirit of the anti-Christ ALREADY in evidence although they said it was of a "later days" thing. I think, rather than fixating on a number, I look for evidence of the spirit of the anti-Christ in modern life (there's plenty of it!
).
Right, we don't need the "anti-Christ" to be a specific person or institution. The spirit of anti-Christ is basically any spiritual message that is... against Christ. That spirit is certainly alive and well today in MANY different people and institutions.
The 666 fixation has always been a kind of boogie man game for some churches. I remember over 20 years ago they were freaking out because the bar-coding was going to be the mark of the beast due to some 666 math in it. I think it was like the thrill people get from watching scary movies. 
Yep, pure "newspaper" eschatology. They use all kinds of crazy math and reasoning to try and correlate modern events to things in the Bible. That's why the rapture, tribulation and return of Christ was predicted so many times in the 20th century and failed every single time.